Hypersensitivity and cross-reactivity to cisplatin and carboplatin.

Faridaalaee, Gholamreza; Rahmani, Seyed Hesam; Mahboubi, Amin

doi:10.15171/jept.2016.09

Document Type : Case Report

Authors

¹ Emergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, Iran

² Emergency Medicine Department, Urmia University of Medical Sciences, Urmia, Iran

https://doi.org/10.15171/jept.2016.09

Abstract

Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergency department (ED) with shortness of breath, tachypnea, restless, agitation, and lethargy. On arrival, the patient was hemodynamically unstable; we initiated treatment immediately with hydration, oxygen therapy with mask, hydrocortisone, midazolam, and adrenalin. After 1 hour, BP and O₂sat improved to 100/70 mm Hg and 92% respectively, but there was not any significant improvement in tachycardia as well as tachypnea and she was still lethargic and agitated. Her symptoms improved gradually after 18 hours of admission. She was discharged after 36 hours. HSRs to cisplatin and carboplatin can be potentially life-threatening. The symptoms can range from a mild rash to severe anaphylaxis. Doctors should be aware of these reactions, determine appropriate treatment, and know the cross-reactivity among these drugs.

Keywords

Main Subjects

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Journal of Emergency Practice and Trauma

Hypersensitivity and cross-reactivity to cisplatin and carboplatin.

References

References

Volume 2, Issue 2
July 2016
Pages 58-61

Hypersensitivity and cross-reactivity to cisplatin and carboplatin.

References

References

Volume 2, Issue 2July 2016Pages 58-61

Volume 2, Issue 2
July 2016
Pages 58-61